Figure 13.

Significant as yet unreported prominent osteogenesis predominantly localized outside the profile of the implanted coral-derived partially converted 5% HA/CC macroporous construct (A) pre-treated with 250 μg recombinant transforming growth factor-β₃ (hTGF-β₃) extending within the rectus abdominis muscle 20 days after heterotopic implantation. (D) Middle-power view showing the rapid expansion of the newly formed bone within the rectus abdominis muscle by 250 μg hTGF-β₃. (B) Partially converted 13% HA/CC macroporous construct pre-treated with 125 μg hTGF-β₃ showing the induction of bone formation outside the implanted macroporous construct (C,E). Middle-power views showing multiple trabeculation of newly formed woven bone also invading the macroporous spaces.