Fig. 3.

Variation of ADC and spin-spin relaxation (T₂) times. Quantitative ADC (a) and T₂ values (b), evaluated from averaging over ten selected regions (0.4 mm²) of interest in the cortical region for 3-monthold and 6-month-old WT mice and P pt1 - KO littermates. Calculated ADC values highlight inherent tissue characteristics as they accentuate possible early changes in water diffusion, due to changes in the microscopic environment, upon the onset of the disease that manifests as increased ADC as early as 3 months of age of the Ppt1-KO mice. In contrast, T₂ which reflects coherence and molecular interactions within this environment shows no significant change.