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. 2012 Mar 6;20(6):1251–1260. doi: 10.1038/mt.2012.36

Figure 7.

Figure 7

Immunohistochenistry and western blot analysis detect that Sleeping Beauty (SB) transposon system-based microRNA-29b (miR-29b) gene transfer attenuates progressive pulmonary fibrosis in an established mouse model of bleomycin-induced pulmonary fibrosis at day 28. (a) Immunohistochemistry staining of collagen I and collagen III. (b–d) Western blot analysis of (b) collagen I, (c) collagen III, and (d) fibronectin (Fn). Each bar represents mean + SEM for at least five mice. *P < 0.05, **P < 0.01, ***P < 0.001 versus saline-treated mice; #P < 0.05, ##P < 0.01 versus control vector treated mice. †P < 0.05, ††P < 0.01 versus bleomycin-treated mice at day 14. BLM, bleomycin; CV, control vector. Bar = 100 µm.