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. Author manuscript; available in PMC: 2012 Sep 28.
Published in final edited form as: J Am Chem Soc. 2011 Sep 2;133(38):14940–14943. doi: 10.1021/ja206743v

Scheme 2.

Scheme 2

First generation synthesis of (+)-naseseazines A (1) and B (2).a

a Conditions: (a) PyHBr3, 2,2,2-trifluoroethanol, 23 °C. (b) (−)-10, AgSbF6, EtNO2, 23 °C; for (+)-11, 13:15=1:1.4, 53%; for (+)-12, 14:16=1:1.4, 47%. (c) H2, Pd/C, AcOH, 23 °C.