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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: CNS Neurol Disord Drug Targets. 2011 Dec;10(8):899–904. doi: 10.2174/187152711799219334

Fig. (4).

Fig. (4)

Efficacy of dAd5GNE in rats. A. Sustained anti-cocaine immunity evoked by dAd5GNE. Total anti-cocaine IgG antibody titers in male Wistar rats vaccinated intramuscularly with 10 µg dAd5GNE plus Adjuplex. Control animals were similarly vaccinated with unconjugated denatured dAd5LacZ. (The Ad5 vector used in the dAd5GNE vaccine.) The vaccine was administered to rats (n=12) at 0, 3, 5, and 10 wk, and the titers (by ELISA) assessed up to 20 wk. Plotted are geometric means and standard deviation. B. Partition of cocaine between brain and blood in naive and dAd5GNE-vaccinated rats (n=5). Levels of cocaine in brain (ng/g brain) and serum (ng/ml serum) of naive and dAd5GNE-vaccinated rats 2 min following [3H]-cocaine challenge (25 µg). The study was at 16 wk post-vaccination. Significance by one-way paired two sample t-test: Brain t = 3.0, p<0.009; serum t = 4.1, p<0.002. Used with permission from Wee et al. [11].