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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: CNS Neurol Disord Drug Targets. 2011 Dec;10(8):899–904. doi: 10.2174/187152711799219334

Fig. (5).

Fig. (5)

Effect of dAd5GNE on suppressing cocaine-induced locomotor activity in rats. Cocaine-induced locomotor activity was assessed upon 8 cocaine challenges over 3 wk. dAd5GNE + Adjuplex vaccinated (■) and naive + cocaine (●) rats (n=8/group) were sensitized to cocaine (15 mg/kg, i.p.) during the 1st wk of the trial and then challenged biweekly with cocaine during wk 2 and 3. Naive rats with PBS challenge were used as a control (Δ). A. Total distance traveled inside an infra-red beam monitored open field apparatus (AccuScan, 40 × 40 cm chambers) in 30 min immediately post cocaine or PBS challenges. All test groups were initially assayed with PBS to establish baseline activity (shown by non-connected symbols at day 0). B. Rat hyperactivity monitored by amount of time spent displaying vertical activity (breaking z-axis beams). Total vertical activity time over 30 min post PBS or cocaine (15 mg/kg) challenges plotted for each trial (n=8/group). Used with permission from Wee et al. [11].