Table 2.
Gene | Genetic variant | Associated variation | Reference | OR Ratio (95% CI)* | P |
---|---|---|---|---|---|
BAX | rs1042265 | G > A | Hosgood et al41 | GA+AA = 0.40 (0.21-0.78) | .007 |
AG (vs AA) = 1.48, (0.94-2.32); | |||||
CASP9 | rs7516435 | A > G | Hosgood et al41 | GG (vs AA) = 2.59 (1.30-5.15) | .005 |
CD4 | rs1075838 | T > C | Lee et al42 | 1.44 (1.05-1.97) | .02 |
CD4 | rs11064392 | A > G | Lee et al42 | 2.36 (1.53-3.63) | .0001 |
CD4 | rs2707212 | C > T | Lee et al42 | 0.68 (0.49-0.96) | .03 |
CD4 | rs7296859 | C > G | Lee et al42 | 0.67 (0.48-0.94) | .02 |
CYP1A1 | CYP1A1*2A | *2A | Kang et al43 | 0.57 (0.33-0.995) | |
HGF | rs17501108 | G > T | Purdue et al44 | GT (vs GG) = 2.65 (1.62-4.35) | < .0001 |
HPSE | rs4693602 | A > G | Ostrovsky et al45 | χ2 statistic = 7.276 | .026 |
IL1A | −889 C/T | C > T | Abazis-Stamboulieh et al46 | CT = 4.18 (2.58-6.55) | < .0001 |
IL1B | −511 C/T | C > T | Abazis-Stamboulieh et al46 | CT = 1.54 (1.20-1.98) | < .0001 |
IL1B | +3954 T/C | T > C | Abazis-Stamboulieh et al46 | CT = 1.38 (1.03-1.84) | < .0001 |
IL-1RN | Mspa1 +11100 | Abazis-Stamboulieh et al46 | TT = 1.35 (1.02-1.79)† | < .0001 | |
IL-6 | rs6684439 | T > C | Birmann et al47 | TT (vs CC) = 2.9 (1.2-7.0) | .048 |
IL-6 | rs7529229 | C > T | Birmann et al47 | CC (vs TT) = 2.5 (1.1-6.0) | .08 |
IL-6 | rs8192284 | C > A | Birmann et al47 | CC (vs AA) = 2.5 (1.1-6.0) | .038 |
IRS1 | rs1801278 | C > T | Birmann et al47 | CT (vs CC) = 4.3 (1.5-12.1) | .68 |
ITGA6 | rs12621278 | A > G | Cooper et al48 | 11.19 (1.56-80.35) | .04 |
KLK3 | rs2735839 | G > A | Cooper et al48 | 0.05 (0.00-0.50) | .07 |
LAG3 | rs2365094 | G > C | Lee et al42 | 1.49 (1.08-2.04) | .01 |
LAG3 | rs3782735 | G > A | Lee et al42 | 0.67 (0.48-0.93) | .02 |
RIPK1 | rs9391981 | G > C | Hosgood et al41 | 0.32 (0.12-0.81) | .005 |
SERPINE1 | rs2227667 | A > G | Purdue et al44 | AG (vs AA) = 0.43 (0.26-0.70) | < .0001 |
TRAF3 | rs12147254 | G > A | Du et al49 | AG (vs GG) = 1 (0.62-0.82) | .001 |
VCAM1 | rs3783605 | A > G | Idelman et al50 | NA | .001 |
XRCC4 | rs963248 | A > G | Hayden et al50 | 1.51 (1.10-2.08) | .0133 |
ULK4 | rs1052501 | G > A | Broderick et al51 | 1.32 (1.20-1.45) | < .0001 |
DNAH11 | rs4487645 | C > A | Broderick et al51 | 1.38 (1.28-1.50) | < .0001 |
DNTB | rs6746082 | A > C | Broderick et al51 | 1.29 (1.17-1.42) | < .0001 |
rs9364554 | G > T | Cooper et al48 | 20.89 (1.88-232.43) | .02 | |
rs2660753 | C > T | Cooper et al48 | 24.33 (2.39-247.56) | .07 | |
rs5759167 | G > T | Cooper et al48 | 11.50 (1.04-127.69) | .06 |
OR unless otherwise noted.