Skip to main content
. 2012 Feb 21;119(23):5359–5366. doi: 10.1182/blood-2011-11-387324

Table 2.

Genetic variation associated with MM

Gene Genetic variant Associated variation Reference OR Ratio (95% CI)* P
BAX rs1042265 G > A Hosgood et al41 GA+AA = 0.40 (0.21-0.78) .007
AG (vs AA) = 1.48, (0.94-2.32);
CASP9 rs7516435 A > G Hosgood et al41 GG (vs AA) = 2.59 (1.30-5.15) .005
CD4 rs1075838 T > C Lee et al42 1.44 (1.05-1.97) .02
CD4 rs11064392 A > G Lee et al42 2.36 (1.53-3.63) .0001
CD4 rs2707212 C > T Lee et al42 0.68 (0.49-0.96) .03
CD4 rs7296859 C > G Lee et al42 0.67 (0.48-0.94) .02
CYP1A1 CYP1A1*2A *2A Kang et al43 0.57 (0.33-0.995)
HGF rs17501108 G > T Purdue et al44 GT (vs GG) = 2.65 (1.62-4.35) < .0001
HPSE rs4693602 A > G Ostrovsky et al45 χ2 statistic = 7.276 .026
IL1A −889 C/T C > T Abazis-Stamboulieh et al46 CT = 4.18 (2.58-6.55) < .0001
IL1B −511 C/T C > T Abazis-Stamboulieh et al46 CT = 1.54 (1.20-1.98) < .0001
IL1B +3954 T/C T > C Abazis-Stamboulieh et al46 CT = 1.38 (1.03-1.84) < .0001
IL-1RN Mspa1 +11100 Abazis-Stamboulieh et al46 TT = 1.35 (1.02-1.79)† < .0001
IL-6 rs6684439 T > C Birmann et al47 TT (vs CC) = 2.9 (1.2-7.0) .048
IL-6 rs7529229 C > T Birmann et al47 CC (vs TT) = 2.5 (1.1-6.0) .08
IL-6 rs8192284 C > A Birmann et al47 CC (vs AA) = 2.5 (1.1-6.0) .038
IRS1 rs1801278 C > T Birmann et al47 CT (vs CC) = 4.3 (1.5-12.1) .68
ITGA6 rs12621278 A > G Cooper et al48 11.19 (1.56-80.35) .04
KLK3 rs2735839 G > A Cooper et al48 0.05 (0.00-0.50) .07
LAG3 rs2365094 G > C Lee et al42 1.49 (1.08-2.04) .01
LAG3 rs3782735 G > A Lee et al42 0.67 (0.48-0.93) .02
RIPK1 rs9391981 G > C Hosgood et al41 0.32 (0.12-0.81) .005
SERPINE1 rs2227667 A > G Purdue et al44 AG (vs AA) = 0.43 (0.26-0.70) < .0001
TRAF3 rs12147254 G > A Du et al49 AG (vs GG) = 1 (0.62-0.82) .001
VCAM1 rs3783605 A > G Idelman et al50 NA .001
XRCC4 rs963248 A > G Hayden et al50 1.51 (1.10-2.08) .0133
ULK4 rs1052501 G > A Broderick et al51 1.32 (1.20-1.45) < .0001
DNAH11 rs4487645 C > A Broderick et al51 1.38 (1.28-1.50) < .0001
DNTB rs6746082 A > C Broderick et al51 1.29 (1.17-1.42) < .0001
rs9364554 G > T Cooper et al48 20.89 (1.88-232.43) .02
rs2660753 C > T Cooper et al48 24.33 (2.39-247.56) .07
rs5759167 G > T Cooper et al48 11.50 (1.04-127.69) .06
*

OR unless otherwise noted.