Figure 1.

Reprogramming efficiency of Fanca^−/− and Fancc^−/− fibroblasts is reduced. (A) Number of iPSC colonies derived from 1 × 10⁵ TTFs 16 days after reprogramming. Filled circles, WT; triangles, Fancc^−/−; open circles, Fanca^−/−. Each symbol represents an individual animal. Horizontal line represents the median. (B) H&E stains of teratomas obtained by subcutaneous injection of Fanca^−/− iPSCs (40× magnification) and fur chimerism in an animal derived by Fanca^−/− iPSC blastocyst injection. **P < .01; *P < .05 by Wilcoxon rank-sum test.