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Mx-Cre deletion of Spry1 worsens, and prolongs, hemolysis-induced anemia. (A) Conditional Spry1−/− and wild-type control mice were challenged by hemolysis (phenylhydrazine [PHZ]; 70 mg/kg). At the indicated intervals, red cell mass was assayed (hematocrits). Values are mean ± SE (n = 4). (B) Analyses of erythroid cells in spleen at day 3.5 after phenylhydrazine revealed an approximate 270% elevation in frequencies of Spry1-deficient stage E1 progenitors.
