Figure 3.

Comparison of the levels of TF in the plasma and activation of coagulation in mice containing orthotopic and subcutaneous HPAF-II tumors. HPAF-II cells were injected into the pancreas (n = 7) or the right flank (n = 6) of nude mice and tumors were grown for 6-8 weeks. Blood was drawn from the IVC and plasma was prepared. Plasma levels of human TF protein (A), MP TF activity (B), TAT (C), and D-dimer (D) were measured and results are shown as means ± SD. Orthotopic HPAF-II pancreatic tumors were grown in nude mice for 8 weeks. Tumor-bearing mice were injected intraperitoneally twice with HTF-1 (n = 4) or mouse IgG (n = 4). Mice were euthanized after 24 hours and blood was collected from the IVC and plasma was prepared. Plasma levels of TAT (E) and D-dimer (F) were measured and are shown as means ± SD. *P < .05.