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. 2011 Sep 14;2(11):667–675. doi: 10.1021/cn200074d

Table 1. Dissociation Constants (Kd) and the Metal Binding Numbers Per Peptide (n) of the Complexes of Metal Ions and Wild Type and Phosphorylated α-syn(107-140).

  Cu(II)
Pb(II)
Fe(II)
Fe(III)
α-syn (107–140) Kd/μM n Kd/μM n Kd/μM n Kd/μM n
wt 203 ± 7 1.9 ± 0.1 240 ± 12 1.7 ± 0.1 72 ± 3 1.5 ± 0.1 52 ± 3 1.8 ± 0.1
pY125 176 ± 6 1.8 ± 0.1 187 ± 5 3.2 ± 0.3 47 ± 6 1.8 ± 0.5 46 ± 2 1.7 ± 0.1
pS129 160 ± 10 1.8 ± 0.2 83 ± 16 1.0 ± 0.2 45 ± 3 2.2 ± 0.3 50 ± 3 1.8 ± 0.1