Table 1. Dissociation Constants (Kd) and the Metal Binding Numbers Per Peptide (n) of the Complexes of Metal Ions and Wild Type and Phosphorylated α-syn(107-140).
| Cu(II) |
Pb(II) |
Fe(II) |
Fe(III) |
|||||
|---|---|---|---|---|---|---|---|---|
| α-syn (107–140) | Kd/μM | n | Kd/μM | n | Kd/μM | n | Kd/μM | n |
| wt | 203 ± 7 | 1.9 ± 0.1 | 240 ± 12 | 1.7 ± 0.1 | 72 ± 3 | 1.5 ± 0.1 | 52 ± 3 | 1.8 ± 0.1 |
| pY125 | 176 ± 6 | 1.8 ± 0.1 | 187 ± 5 | 3.2 ± 0.3 | 47 ± 6 | 1.8 ± 0.5 | 46 ± 2 | 1.7 ± 0.1 |
| pS129 | 160 ± 10 | 1.8 ± 0.2 | 83 ± 16 | 1.0 ± 0.2 | 45 ± 3 | 2.2 ± 0.3 | 50 ± 3 | 1.8 ± 0.1 |