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. 2011 Oct 13;2(12):694–699. doi: 10.1021/cn200088r

Figure 3.

Figure 3

Sugar-curcumin inhibits amyloid-β assembly at lower concentrations than regular curcumin. Amyloid-β peptides 25–35 (A) and 1–42 (B) were incubated with 8 μM or 8 nM of SC or curcumin. It is shown that, at 8 nM concentration, SC is able to significantly inhibit aggregation. Curcumin is only able to inhibit aggregation at micromolar concentrations. The assembly is shown by negatively stained electron microscopy (all scale bars are 500 nm). (C) Dot blot assay of Aβ 1–42. TEM microscopy results were confirmed by immuno dot blot assay. Note: P, pellet; S, supernatant.