Table 2. Chemical Structures and Binding Affinities of Quinoxaline-2,3-dione Analogues 2.1−2.7 at Native iGluRs (Rat Synaptosomes)^a.

cmpd	R1	R2	KA	AMPA	NMDA/Gly
2.1b	CF3	H	3.4	0.015	>30
2.2c	CF3	3-COOEt	1.2	0.004	>30
2.3c	CF3	4-COOEt	0.7	0.004	>30
2.4b	CF3	4-Br	0.11	0.004	>30
2.5b	CF3	4-CF3	0.11	0.005	>30
2.6d	CF3		1.5	0.17	8.0
2.7d	NO2		0.41	0.070	>25

^aAll values are K_i in [μM]. Radioligands used: AMPA, [³H]AMPA; GluK1-3,5, [³H]KA radioligand.

^bFrom ref (60).

^cFrom ref (61).

^dFrom ref (62).