. 2010 Dec 10;2(2):60–74. doi: 10.1021/cn1001039

Table 4. Chemical Structures and Binding Affinities (K_i) of Quinoxaline-2,3-dione Derivatives 4.1−4.6 at Native AMPA Receptors^a.

cmpd	X	R	AMPA	GluK1	GluK2	GluK3	GluK5
4.1 (BSF-84077)^c			>23	0.43	23	−^b	>30
4.2^c	CH₂		3.0^d	0.33	28	5.7	>30
4.3^c	CH	Ph	−^b	0.23	3.6	0.53	18
4.4^c	N	PhCH2CH2-	−^b	0.012	1.4	1.4	25
4.5 (BSF-91594) ^c	N	Ph−CH2-	0.25	0.0038	4.1	0.68	20
4.6^c			0.005^d	0.10	0.61	0.046	12

All values in [μM]. Radioligands used: AMPA, [³H]AMPA; GluK1-3,5, [³H]KA radioligand.

Not tested.

From ref (64).

From ref (60).

Table 4. Chemical Structures and Binding Affinities (Ki) of Quinoxaline-2,3-dione Derivatives 4.1−4.6 at Native AMPA Receptorsa.