Table 5. Chemical Structures and Pharmacological Profile of Isatin Oxime Analogues 5.1−5.3^a.

	GluA1		GluA2	GluK1		GluK2
cmpd	bind.	func.	bind.	bind.	func.	bind.	func.
5.1 (NS 102)	−b	−b	−b	−b	6c	1.4d	−b
5.2 (NS 257)e	−b	0.97	−b	−b	−b	−b	2.3
5.3 ((R/S)-NS 1209)	0.12g	−b	0.030g	0.74g	0.63f	6.2g	65f

^aAll values in [μM].

^bNot tested.

^cK_B value for inhibition of Ca²⁺ influx in rat dorsal root ganglion (DRG) neurons; from ref (49),.

^dDisplacement of [³H]KA radioligand; from ref (65).

^eIC₅₀ values for inhibition of KA-induced depolarization in the appropriate mRNA-injected Xenopus oocytes; from ref (67).

^fIC₅₀ values for inhibition of domoate-induced currents in HEK293 cells; from ref (68).

^gDisplacement of [³H]AMPA radioligand; from ref (69).