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Reagents and conditions: (a) NaCN, DMSO, 70 °C, 24 h; (b) NaOH, methanol, 70 °C, 15 h; (c) 48, EDC, HOBt, DCM, RT, 3 h; (d) NaOAc, ethanol, water, 85 °C, 5 h; (e) TFA, RT, 0.5 h; (f) 47, 2-propanol, DIPEA, 85 °C, 7 h; (g) 6N HCl, methanol, 60 °C, 0.5 h.
