Table 2. In Vitro Binding Data for Phenyl-Oxadiazoles^a.

			NR2B	hERG
compd	C3	R1	Ki (nM)b	IP (nM)c
9	S	H	31	8200
10	R	H	330	18000
11	S	2-CH3	120	5500
12	S	3-CH3	150	9500
13	S	4-CH3	7.9	6300
14	S	4-Cl	10	21000

^aAll values are the geometric mean of at least n = 4 measurements.

^bInhibition of ³H-[(E)-N¹-(2-methoxybenzyl)-cinnamamidine] binding to hNR1a/NR2B receptors expressed in Ltk- cells.⁴³

^cInhibition of MK-499 binding to hERG in HEK293 cells.⁴⁴