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. 2011 Apr 15;2(7):352–362. doi: 10.1021/cn200013d

Table 3. In Vitro Binding Data for Cyclopentyl-Oxadiazolesa.

graphic file with name cn-2011-00013d_0013.jpg

      NR2B hERG
compd m n Ki (nM)b IP (nM)c
9 0 0 31 8200
15 0 1 31 7200
16 1 0 6.2 28000
17 2 0 120 7400
a

All values are the geometric mean of at least n = 4 measurements.

b

Inhibition of 3H-[(E)-N1-(2-methoxybenzyl)-cinnamamidine] binding to hNR1a/NR2B receptors expressed in Ltk- cells.43

c

Inhibition of MK-499 binding to hERG in HEK293 cells.44