Table 2. Biodistribution of Radioactivity after Intravenous Administration of [125I]RH1, [125I]TH1, and [125I]TH2 in Micea.
| time after injection (min) |
||||
|---|---|---|---|---|
| tissue | 2 | 10 | 30 | 60 |
| [125I]RH1 | ||||
| blood | 6.70 (0.53) | 3.58 (0.37) | 2.27 (0.44) | 1.59 (0.14) |
| liver | 43.06 (2.07) | 29.52 (2.17) | 14.74 (2.27) | 11.30 (0.87) |
| kidney | 8.50 (0.83) | 7.64 (0.69) | 6.42 (1.17) | 3.91 (0.18) |
| intestine | 1.77 (0.33) | 7.97 (1.24) | 15.07 (1.82) | 21.03 (2.73) |
| spleen | 6.70 (0.54) | 4.11 (0.80) | 2.66 (0.84) | 1.94 (0.40) |
| pancreas | 1.74 (0.19) | 1.75 (0.18) | 1.6 (0.17) | 0.73 (0.08) |
| heart | 9.41 (0.49) | 5.05 (0.39) | 2.38 (0.38) | 1.39 (0.19) |
| stomachb | 0.52 (0.03) | 1.16 (0.16) | 2.75 (0.36) | 2.94 (0.51) |
| brain | 0.23 (0.02) | 0.16 (0.01) | 0.15 (0.03) | 0.11 (0.02) |
| [125I]TH1 | ||||
| blood | 9.49 (0.82) | 2.38 (0.88) | 1.79 (0.11) | 1.50 (0.10) |
| liver | 32.19 (1.67) | 32.11 (2.09) | 22.60 (3.42) | 20.18 (1.93) |
| kidney | 9.21 (0.68) | 9.311 (1.15) | 3.86 (0.85) | 2.68 (0.75) |
| intestine | 1.85 (0.26) | 7.88 (1.46) | 17.73 (2.22) | 23.40 (5.37) |
| spleen | 9.16 (2.04) | 12.21 (2.28) | 13.58 (4.29) | 10.04 (2.49) |
| pancreas | 1.79 (0.27) | 0.98 (0.08) | 0.56 (0.10) | 0.45 (0.08) |
| heart | 7.02 (1.23) | 2.05 (0.29) | 1.19 (0.33) | 1.44 (0.39) |
| stomachb | 0.62 (0.22) | 2.47 (2.41) | 2.13 (1.01) | 3.30 (1.40) |
| brain | 0.57 (0.0.7) | 0.32 (0.02) | 0.18(0.02) | 0.10 (0.03) |
| [125I]TH2 | ||||
| blood | 8.16 (1.21) | 2.77 (0.21) | 2.11 (0.28) | 1.48 (0.27) |
| liver | 34.99 (2.27) | 33.32 (1.41) | 27.22 (2.05) | 22.75 (2.13) |
| kidney | 12.48 (0.76) | 7.34 (0.70) | 4.97 (0.71) | 3.37 (0.30) |
| intestine | 2.55 (0.16) | 7.41 (1.21) | 17.32 (1.67) | 23.58 (2.39) |
| spleen | 9.23 (0.63) | 10.87 (2.78) | 8.51 (2.68) | 8.46 (2.57) |
| pancreas | 3.30 (0.86) | 2.15 (0.23) | 1.15 (0.18) | 0.86 (0.08) |
| heart | 8.48 (0.97) | 2.78 (0.19) | 1.73 (0.18) | 1.30 (0.37) |
| stomachb | 0.87 (0.07) | 1.70 (1.14) | 2.78 (0.68) | 5.94 (4.80) |
| brain | 1.54 (0.10) | 1.30 (0.12) | 0.66 (0.08) | 0.25 (0.02) |
a
Expressed as % injected dose per gram. Each value represents the mean (s.d.) for 5 animals at each interval.
b
Expressed as % injected dose per organ.