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. 2011 Jun 27;2(8):450–470. doi: 10.1021/cn2000519

Figure 4.

Figure 4

Structures of ADX-47273 analogues with “molecular locks” and subtle “molecular switches”: 2- vs 3-substituted piperidines (26–28), transfer of “molecular switch” to 2-substituted pyrrolidine ring system and stereochemical preference (29).