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Modified fluorescence polarization (FP) based time course assays to evaluate tolcapone and methylated derivatives as COMT substrates. (A–D) 1 μM tolcapone or 2 μM dopamine provided as substrates for human MB-COMT, rat MB-COMT, human S-COMT, or rat S-COMT. (E) 1 μM 4-methoxy-tolcapone or 1 μM 3-methoxy-tolcapone provided as substrates for rat S-COMT.
