. 2011 Nov 14;3(2):129–140. doi: 10.1021/cn200109w

Table 2. Effect of Single Dose Administration of Tolcapone or Novel Non-Nitrocatechol Compounds 3–14 on COMT Activity in Blood, Brain, or Liver as well as CSF DOPAC and HVA Levels in Male Wistar Rat^a.

Data were normalized to separate vehicle treated rats for each respective time point and data expressed as 100% of control. CSF biomarker values that significantly differed from vehicle were determined using regular two-way ANOVA followed by post-hoc tests using a Dunnett correction factor for individual group comparisons as indicated; *p <0.05, **p < 0.01, ***p < 0.001. A significant effect on COMT ex vivo activity versus vehicle was determined using an unpaired t test as indicated; *p <0.05, **p < 0.01, ***p < 0.001.

Table 2. Effect of Single Dose Administration of Tolcapone or Novel Non-Nitrocatechol Compounds 3–14 on COMT Activity in Blood, Brain, or Liver as well as CSF DOPAC and HVA Levels in Male Wistar Rata.

Table 2. Effect of Single Dose Administration of Tolcapone or Novel Non-Nitrocatechol Compounds 3–14 on COMT Activity in Blood, Brain, or Liver as well as CSF DOPAC and HVA Levels in Male Wistar Rat^a.