Table 5. Indolinone Dervivatives as LRRK2 Inhibitors.

		IC50
no.	name	wild-type LRRK2	LRRK2-G2019S	substrate	selectivitya	in vivo	lit.
9	Raf-1 kinase inhibitor I (GW5074)	∼500 nM;b3150 nMc	880 nMc	LRRKtide; MBPd	2	HSVg amplicon-based mouse model	(58, 61)
10	Indirubin-3′-monooxime	4830 nMc	1310 nMc	MBPd	2	HSVg amplicon-based mouse model	(58)
11	Sunitinib	79 nM;e 15 nMf	19 nM;e 26 nMf	Nictide; LRRKtide	85		(60, 63, 65)

^aNumber of all kinases, including LRRK2.

^bGoat GST-LRRK2.

^cGST-LRRK2 (wt/G2019S).

^dMyelin basic protein (MBP).

^eGST-LRRK2 (1326–2527; wt/G2019S).

^fGST-LRRK2 (970–2527; wt/G2019S).

^gHerpes simplex virus.