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. 2012 Jan 18;3(3):151–160. doi: 10.1021/cn200117j

Table 7. Y-27632 as LRRK2 Inhibitor.

graphic file with name cn-2011-00117j_0007.jpg

    IC50
        
no. name wild-type LRRK2 LRRK2-G2019S substrate selectivitya in vivo lit.
14 Y-27632 2300 nMb 1800 nM;c 1000 nMb GST-Moesin; Nictide 85   (62, 63)
a

Number of all kinases, including LRRK2.

b

GST-LRRK2 (1326-2527; wt/G2019S).

c

Full-length Strep-tag LRRK2 (G2019S).