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. Author manuscript; available in PMC: 2012 Jun 7.
Published in final edited form as: Biosens Bioelectron. 2010 Jul 1;26(2):778–783. doi: 10.1016/j.bios.2010.06.025

Figure 4.

Figure 4

Phase contrast and fluorescence microscopic images of FITC-ODNs uptake by K562 cells, which were treated with (a) medium only (negative control); (b) free ODNs; nanotargeted FITC-ODNs encapsulated lipoplex nanoparticles, (c) non-Tf-LNs-G3139 alone, (d) non-Tf-LNs-G3139 + BE, and (e) non-Tf-LNs-G3139 + SFE; Tf-targeted FITC-ODNs encapsulated lipoplex nanoparticles, (f) Tf-LNs-G3139 alone, (g) Tf-LNs-G3139 + BE, and (h) Tf-LNs-G3139 + SFE. The FITC-ODNs concentration was set at 2 μM. BE: Bio-Rad Xcell Pulser Bulk Electorporation, 2 mm cuvette; SFE: semi-continuous flow electroporation. Electroporation conditions: unipolar square wave pulses with a pulse duration of 25 ms for both BE and SFE. The scale bars represent 100 μm.