Table 2. Clinical characteristics of the primary cohort of patients with MM (TMA 1).

	High risk (N = 181)	Low risk (N = 181)	p-Value: high vs. low risk	Hazard ratio (95% CI) #3	p-Value #3
7-Marker risk score	0.267±0.092	0.0017±0.12	<<0.0001#1	5.1 (1.4–18.2)	0.012*
Age – yr	59.5±15.0	57.7±14.9	0.263#1	1.03 (1.02–1.05)	0.000011***
Tumor thickness – mm	2.52±2.38	1.40±2.21	0.00000646#1	1.05 (0.97–1.14)	0.24
Clark level	3.66±0.739	2.93±0.83	<<0.0001***	1.8 (1.4–2.5)	0.000098***
Sex – no. of patients (%)
Male	105 (58)	89 (49.2)	1#2	1.9 (1.3–2.8)	0.0019**
Female	76 (42)	92 (50.8)
Nodal status (%)
N0	158 (90.8)	159 (95.8)	0.084#2	1.6 (0.8–3.2)	0.15
N1-N3	16 (9.2)	7 (4.22)

^#1Welch two sample t-test,

^#2Fisher’s exact test,

^#3Multivariate Cox regression,

^***p-Value <0.001.

Comparing high-risk patients (first column) with low-risk patients (second column) based on their seven-marker risk score showed a significant difference in tumor thickness (p<0.001) and Clark levels (p<0.001), and no difference in nodal status (p = 0.084), sex (p = 1) and age (p = 0.263). Furthermore, hazard ratios and p-values were reported for a multivariate Cox regression model comprising all listed variables. Regarding overall survival the seven-marker risk score was statistically significant (p<0.05) independent of sex, age, nodal status, clark level and tumor thickness. Continuous variables are reported with mean and standard deviation and categorical variables are listed with number of counts and percentages.