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. 2012 Jun 7;7(6):e37995. doi: 10.1371/journal.pone.0037995

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Tian et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Images of histological analysis show severe intraocular inflammation in PBS (a,b) and AAV2.GFP injected eyes (c,d) compared with AAV2.IFN-α treated (e,f), AAV2.IL-4 treated (g,h), and AAV2.IFN-α combined with AAV2.IL-4 treated eyes (i,j). (haematoxylin eosin staining, original magnification×100). EAU was significantly reduced in AAV2.IL-4 treated group, AAV2.IL-4 combined with AAV2.IFN-α treated group as compared with controls (k) (p<0.0001, Mann-Whitney U test). The AAV2.IFN-α treated group also shows a significantly decreased uveitis (p = 0.005). Each point is the score of an individual eye. The mean scores of each group are denoted by the horizontal bars.