Table 4. Mean differences (95% confidence intervals, CI) in birth size as predicted by the additive effects of neighborhood social disparity and at least one risk allele (CCNL1/LEKR1- rs900400).
| Mean difference (95% CI) P value | ||||||||||||
| Birth weight (g) | Birth Length(cm) | Head circumference (cm) | Ponderal index (kg/m3) | |||||||||
| Exposure: | n * | Unadjusted | Adjusted** | n * | Unadjusted | Adjusted** | n * | Unadjusted | Adjusted** | n * | Unadjusted | Adjusted** |
| Neither disparity nor riskallele [ref] | 875 | 871 | 858 | 871 | ||||||||
| At least one risk allele only | 1044 | −39.7 | −63.5 | 1038 | −0.006 | −0.10 | 1024 | −0.11 | −0.17 | 1038 | −0.34 | −0.35 |
| (−84.1, 4.6) | (−101.4, −25.6) | (−0.19, 0.18) | (−0.26, 0.05) | (−0.23, 0.02) | (−0.30, −0.06) | (−0.54, −0.14) | (−0.56, −0.15) | |||||
| 0.07 | 0.001 | 0.95 | 0.20 | 0.10 | 0.003 | 0.0008 | 0.0007 | |||||
| Social disparity only | 1158 | −11.8 | −35.5 | 1151 | −0.12 | −0.16 | 1137 | −0.06 | −0.12 | 1151 | 0.02 | −0.05 |
| (−55.2, 31.5) | (−72.4, 2.0) | (−0.30, 0.06) | (−0.32, 0.007) | (−0.19, 0.06) | (−0.24,−0.01) | (−0.17, 0.22) | (−0.25, 0.15) | |||||
| 0.59 | 0.06 | 0.18 | 0.04 | 0.30 | 0.03 | 0.83 | 0.65 | |||||
| Both disparity and at leastone risk allele | 1427 | −54.7 | −108.5 | 1415 | −0.14 | −0.31 | 1403 | −0.12 | −0.25 | 1415 | −0.24 | −0.37 |
| (−96.3, −13.0) | (−144.1, −72.9) | (−0.31, 0.04) | (−0.46, −0.16) | (−0.24, −0.006) | (−0.35, −0.14) | (−0.43, −0.05) | (−0.56, −0.17) | |||||
| 0.01 | <0.0001 | 0.12 | <0.0001 | 0.04 | <0.0001 | 0.01 | 0.0002 | |||||
| P value for trend | <0.0001 | <0.0001 | <0.0001 | 0.008 | ||||||||
*
n in the adjusted model,
**
controlling for gestational age, maternal smoking, maternal alcohol consumption, parity, maternal pre-pregnancy BMI, sex, gestational diabetes and hypertension during pregnancy.