Table 1. Clonal Mitochondrial DNA Mutations Identified in Colorectal Tissue.
Patient ID | Tissue | Gene | DNA | Protein |
2 | Carcinoma | COXII | 7859G>A | D92N |
COXIII | 9451G>A | G82E | ||
4 | Carcinoma | non-coding | 5894insC | |
Cyt b | 15375G>A | G210E | ||
5 | Carcinoma | D-loop | 508A>G | |
6 | Carcinoma | COXIII | 9645G>A | A147T |
7 | Carcinoma | D-loop | 523delAC | |
12S rRNA | 1598G>A | |||
ND2 | 4707C>T | L80F | ||
10 | Carcinoma | ND4L | 10675G>A | C69Y |
ND5 | 13239C>A | I301M | ||
D-loop | 16465C>T | |||
11 | Carcinoma | D-loop | 72T>C | |
D-loop | 309insC | |||
COXI | 6121T>C | I73T | ||
COXIII | 9439G>A | G78D | ||
17 | Carcinoma | ND5 | 12426insA | frameshift |
D-loop | 16298C>T | |||
D-loop | 16390G>A | |||
18 | Carcinoma | ND1 | 3745G>A | A147T |
ND5 | 13133delT | frameshift | ||
19 | Carcinoma | ND5 | 13970G>A | S545N |
20 | Carcinoma | D-loop | 524insAC | |
16S rRNA | 2957G>A | |||
18 | Adenoma | ND5 | 13193T>C | L286P |
19 | Adenoma | D-loop | 66delG | |
ND1 | 4142G>A | R279Q | ||
COXII | 8251G>A | |||
ND4 | 11711G>A | A318T | ||
D-loop | 16183insC | |||
20 | Adenoma | D-loop | 524insAC | |
16S rRNA | 2957G>A | |||
69 | Adenoma | ND1 | 3571insC | frameshift |
ND2 | 5450C>T | |||
70 | Adenoma | tRNA M | 4465T>C | |
Cyt b | 15448C>T | |||
74 | Adenoma | 12S rRNA | 1045G>A | |
COXII | 8141G>A | A186T | ||
ND4 | 10952insC | frameshift | ||
D-loop | 16166A>G | |||
D-loop | 16309A>G |