Table 3. Association between genetic variants at chromosome 1q41 and high myopia in the five Asian cohorts.
| Japan Dataset 1 (483/1,194)c | Japan Dataset 2 (504/550) | SCESb (44/1,305) | SCORMb (65/332) | SiMESb (22/2,052) | Meta–analysis (1,118/5,433) | ||||||||||
| SNP | BP | MAa | ORd (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | Pmeta | Phet e |
| rs4428898 | 217806589 | G | 0.74 (0.64, 0.87) | 2.33×10−4 | 0.76 (0.64, 0.91) | 2.15×10−3 | 0.73 (0.45, 1.19) | 2.06×10−1 | 0.63 (0.40, 0.99) | 4.89×10−2 | 0.72 (0.32, 1.64) | 4.37×10−1 | 0.74 (0.66, 0.83) | 7.86×10−8 | 0.96 |
| rs4373767 | 217826305 | C | 0.74 (0.63, 0.86) | 1.44×10−4 | 0.81 (0.68, 0.96) | 1.80×10−2 | 0.73 (0.44, 1.18) | 1.99×10−1 | 0.59 (0.38, 0.94) | 2.59×10−2 | 0.77 (0.35, 1.69) | 5.16×10−1 | 0.75 (0.68, 0.84) | 4.38×10−7 | 0.75 |
| rs10779363 | 217853513 | C | 0.74 (0.63, 0.87) | 2.11×10−4 | 0.81 (0.68, 0.96) | 1.41×10−2 | 0.68 (0.41, 1.13) | 1.35×10−1 | 0.62 (0.39, 0.98) | 4.13×10−2 | 0.76 (0.34, 1.68) | 4.96×10−1 | 0.76 (0.68, 0.85) | 7.81×10−7 | 0.82 |
| rs7544369 | 217856085 | T | 0.75 (0.64, 0.88) | 3.05×10−4 | 0.82 (0.69, 0.97) | 2.32×10−2 | 0.67 (0.39, 1.15) | 1.45×10−1 | 0.62 (0.39, 0.98) | 4.17×10−2 | 0.74 (0.33, 1.64) | 4.56×10−1 | 0.76 (0.69, 0.85) | 1.45×10−6 | 0.79 |
a
MA, minor allele.
b
GWAS cohorts; SCES - Singapore Chinese Eye Study; SCORM - Singapore Cohort study of the Risk factors for Myopia; SiMES - Singapore Malay Eye Study.
c
The sample sizes for each study denote the number of high-myopia cases versus controls. For the Japan dataset 1, high myopia, AL≥28mm for both eyes; controls, general healthy population; For the Japan dataset 2, SCES, and SiMES, high myopia, SE≤−9.0 D for either eye; controls, SE≥−3.0 D for both eyes; For SCORM children, high myopia, SE≤−6.0 D for either eye; controls, SE≥−1.0 D for both eyes.
d
OR, odds ratio per copy of minor allele.
e
Phet, P-value for heterogeneity by Cochran's Q test across five study cohorts.