Fig. 2.

a Mammary analogue secretory carcinoma with nodular growth, well-defined border, and combination of microfollicular growth (lower half of the image) with more solid growth, H&E, 40×. b Mammary analogue secretory carcinoma, glands are filled with colloid-like secretions. The cytoplasm is vacuolated and shows no basophilic zymogen granules. The lymphoid infiltrate in the left upper corner is part of a moderate tumor-associated lymphoid response. H&E, 400×. c Neoplastic cells express S100, immunohistochemistry, 100×. dETV6 (12p13) FISH with break-apart probes. ETV6 translocation is indicated by the split of red and green signals. Chromosomes with intact ETV6 gene show a yellow signal (overlapping of green and red signals)