Table 1.
Characteristics of study participants
| Age (Yrs) | Diagnosis | Gonadotoxic treatment Prior to OTC | Planned treatment | FSH mlU/mL | Specimen | Other fertility preservation options pursued | |
|---|---|---|---|---|---|---|---|
| 1 | 8 | Acute Myelogenous Leukemia | Yes | Stem Cell Transplantation | 3.8 | Biopsy | None |
| 2 | 10 | Sickle-Cell Anemia | Yes | Stem Cell Transplantation | 0.03 | Biopsy | None |
| 3 | 11 | Neuroblastoma | Yes | Stem Cell Transplantation | 83.8 | Biopsy | None |
| Abdominal Radiotherapy | |||||||
| 4 | 12 | Pineoblastoma | No | Stem Cell Transplantation | 1.3 | Biopsy | Ovarian transposition at time of ovarian biopsy |
| Craniospinal Radiotherapy | |||||||
| 5 | 14 | Acute Myelogenous Leukemia | Yes | Stem Cell Transplantation | 8.0 | Biopsy | None |
| 6 | 14 | Myelodysplastic Syndrome | No | Stem Cell Transplantation | 7.9 | Biopsy | None |
| 7 | 15 | Medulloblastoma | No | Chemotherapy (Cyclophosphamide) | 2.0 | Biopsy | Ovarian transposition at time of ovarian biopsy |
| Craniospinal Radiotherapy | |||||||
| 8 | 16 | Ewing Sarcoma | No | Chemotherapy (Ifosfamide and Cyclophosphamide) | 7.0 | Biopsy | None |
| 9 | 17 | Rhabdo-myosarcoma | Yes | Chemotherapy (Ifosfamide and Cyclophosphamide) | 6.2 | Biopsy | None |
| Radiotherapy | |||||||
| 10 | 18 | Ewing’s Sarcoma | No | Chemotherapy (Ifosfamide and Cyclophosphamide) | 0.8 | Biopsy | None |
| 11 | 18 | Central Nervous System Germinoma | No | Craniospinal Radiotherapy | 0.19 | Biopsy | Ovarian transposition at the time of ovarian biopsy |
| 12 | 20 | Hodgkin Lymphoma | Yes | Stem Cell Transplantation | 8.4 | Biopsy | Failed ovarian stimulation |
| 13 | 24 | Breast Cancer | No | Chemotherapy (ACT) | 7.3 | Biopsy | None |
| 14 | 25 | Acute lymphoblastic leukemia | Yes | Stem Cell Transplantation | 1.0 | Ovary | Failed ovarian stimulation |
| 15 | 26 | Breast Cancer | No | Chemotherapy (ACT) | 0.6 | Biopsy | None |
| 16 | 26 | Chronic Myelogenous Leukemia | Yes | Stem Cell Transplantation | 2.2 | Ovary | Ovarian stimulation with 7 oocytes banked |
| 17 | 29 | Cervical Cancer | No | Pelvic Radiotherapy and Chemotherapy (Cisplatin) | 4.7 | Biopsy | Ovarian transposition at time of ovarian biopsy |
| 18 | 32 | Hodgkin Lymphoma | Yes | Pelvic Radiotherapy | 12.1 | Biopsy | IVF with 4 embryos banked |
| Ovarian transposition at time of ovarian biopsy | |||||||
| 19 | 35 | Non-Hodgkin Lymphoma | Yes | Chemotherapy (R-CHOP) | 5.3 | Biopsy | None |
| 20 | 36 | Breast Cancer | No | Chemotherapy (ACT) | 8.8 | Ovary | None |
| 21 | 36 | Anaplastic Large Cell Lymphoma | No | Chemotherapy (Cyclophosphamide, Adriamycin, Vincristine) | 5.4 | Biopsy | None |
ACT = Doxarubicin, Cyclophosphamide, Paclitaxel
RCHOP = Rituximab, Cyclophophamide, Doxorubicin, Vincristine