. 2012 Mar 30;29(6):565–572. doi: 10.1007/s10815-012-9750-x

Table 4.

Endpoints for IVF embryos only

IVF only	ITT/PP	TLI	COI	RR_TLI/STI	RD_TLI/STI	p-value*
Number of randomized oocytes	ITT	n = 131	n = 129	–	–	–
Number of randomized oocytes	PP	n = 117	n = 114	–	–	–
Number of four-cells day 2	ITT	n = 35	n = 41	0.84 (0.57;1.23)	−5.1 % (−16.1;6.0)	0.37
Number of four-cells day 2	PP	n = 27	n = 35	0.75 (0.49;1.16)	−7.6 % (−19.0;3.8)	0.19
Number of 7–8 cells day 3	ITT	n = 31	n = 29	1.05 (0.68;1.64)	1.2 % (−9.1;11.4)	0.82
Number of 7–8 cells day 3	PP	n = 26	n = 26	0.97 (0.60;1.57)	−0.6 % (−11.4;10.2)	0.92
Number of blastocysts day 5	ITT	n = 35	n = 36	0.96 (0.64;1.42)	−1.2 % (−12.0;9.6)	0.83
Number of blastocysts day 5	PP	n = 30	n = 33	0.89 (0.58;1.35)	−3.3 % (−14.8;8.2)	0.57

RR Risk Ratio; RD Risk Difference

TLI Time-lapse incubator; COI Conventional incubator

ITT Assessed by intention-to-treat; PP Assessed per protocol

*Time-lapse incubator compared with conventional incubator