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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Hum Mutat. 2012 Apr 16;33(7):1037–1044. doi: 10.1002/humu.22081

Figure 2. Pre-rRNA processing in human cells.

Figure 2

The early 47S precursor is processed along different pathways depending on the order of the cleavages. Given the higher abundance of 30S pre-rRNA relative to the 41S species, cleavage of the ITS1 at site 2 appears to occur most frequently before processing of the 5′-ETS. Arrowheads indicate the pre-rRNA endonucleolytic cleavage sites, although some processing steps involve exonucleases rather than endonucleases. Dashed lines indicate the hypothetical pathway induced by RPL26 depletion.