Table I.
Top functional categories represented by differentially expressed genes in lungs from anti-LIF treated mice compared to controls during pneumonia1
| Molecular and Cellular Functions | p-value | Gene # |
|---|---|---|
| Cell Death | 8.8E-06–1.69E-02 | 398 |
| Small Molecule Biochemistry | 3.84E-09-1.69E-02 | 349 |
| Post-Translational Modification | 2.82E-12-1.49E-02 | 338 |
| Cellular Assembly and Organization | 2.86E-06-1.5E-02 | 331 |
| Molecular Transport | 3.31E-05-1.49E-02 | 308 |
| Cell Cycle | 7.57E-07-1.68E-02 | 291 |
| Lipid Metabolism | 3.84E-09-1.57E-02 | 274 |
| Cellular Function and Maintenance | 2.86E-06-1.5E-02 | 245 |
| Protein Degradation | 3.64E-05-9.9E-03 | 95 |
| Energy Production | 1.07E-07-8.9E-03 | 71 |
1
Transcriptional profiling was performed on lung RNA collected 24 hrs after i.t. E. coli in mice co-treated with anti-LIF or control IgG (n = 3). Ingenuity Pathway Analysis was used to determine molecular and cellular functions significantly represented (p < 0.05) by all differentially expressed transcripts (FDR < 0.05; no fold cutoff). The 10 most significant categories are shown along with the number of differentially expressed genes comprising the indicated function.