Table II.
Top 10 induced genes in anti-LIF treated mice compared to controls during pneumonia1
| Symbol | Name | FDR | Fold Change |
|---|---|---|---|
| Fap | fibroblast activation protein | 0.015 | ↑7.51 |
| Mx2 | myxovirus (influenza virus) resistance 2 | 0.017 | ↑6.83 |
| Fosb | FBJ osteosarcoma oncogene B | 0.042 | ↑5.70 |
| Stfa1 | stefin A1 | 0.035 | ↑5.18 |
| Dio2 | deiodinase, iodothyronine, type II | 0.039 | ↑4.72 |
| Tas2r135 | taste receptor, type 2, member 135 | 0.030 | ↑4.67 |
| Tnfrsf11b | tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) | 0.026 | ↑4.25 |
| Sprr1a | small proline-rich protein 1A | 0.016 | ↑3.98 |
| Il24 | interleukin 24 | 0.033 | ↑3.96 |
| Tnfsf15 | tumor necrosis factor (ligand) superfamily, member 15 | 0.011 | ↑3.75 |
1
Transcriptional profiling was performed on lung RNA collected 24 hrs after i.t. E. coli in mice co-treated with anti-LIF or control IgG (n = 3). Fold change was ranked amongst all differentially expressed transcripts (FDR < 0.05). The 10 most up-regulated genes are shown.