Table III.
Top 10 reduced genes in anti-LIF treated mice compared to controls during pneumonia1
| Symbol | Name | FDR | Fold Change |
|---|---|---|---|
| Sntn | sentan, cilia apical structure protein | 0.015 | ↓11.77 |
| Fmo3 | flavin containing monooxygenase 3 | 0.011 | ↓9.15 |
| Cckar | cholecystokinin A receptor | 0.009 | ↓7.36 |
| Rsph4a | radial spoke head 4 homolog A (Chlamydomonas) | 0.014 | ↓6.98 |
| Hsd11b2 | hydroxysteroid 11-beta dehydrogenase 2 | 0.007 | ↓6.91 |
| Cmbl | carboxymethylenebutenolidase-like (Pseudomonas) | 0.019 | ↓6.76 |
| Atp6v0d2 | ATPase, H+ transporting, lysosomal V0 subunit D2 | 0.034 | ↓6.48 |
| l7Rn6 | lethal, Chr 7, Rinchik 6 | 0.020 | ↓6.24 |
| Mettl4 | methyltransferase like 4 | 0.024 | ↓6.06 |
| Clec1a | C-type lectin domain family 1, member a | 0.017 | ↓5.82 |
1
Transcriptional profiling was performed on lung RNA collected 24 hrs after i.t. E. coli in mice co-treated with anti-LIF or control IgG (n = 3). Fold change was ranked amongst all differentially expressed transcripts (FDR < 0.05). The 10 most down-regulated genes are shown.