Table 1.
Characteristics of patients
| Molecular Cohort | |||||
|---|---|---|---|---|---|
| Characteristic | ALK+ | EGFR+ | KRAS+ | Triple Negative |
Total |
| Total | 41 (20) | 39 (19) | 49 (23) | 80 (38) | 209 |
| Histology | |||||
| Adenocarcinoma | 38 (93) | 37 (95) | 47 (96) | 78 (98) | 200 (96) |
| Large cell | 1 (2) | 0 | 2 (4) | 0 | 5 (2) |
| NOS | 2 (5) | 2 (5) | 0 | 2 (3) | 6 (3) |
| Staging | |||||
| Stage IV at diagnosis | 35 (85) | 28 (72) | 39 (80) | 63 (79) | 165 (79) |
| Recurrent disease | 6 (15) | 11 (28) | 10 (20) | 17 (21) | 44 (21) |
| Smoking history | |||||
| Never (<100 cigarettes) | 31 (76) | 22 (56) | 6* (12) | 25 (31) | 84 (40) |
| Light (≤10 py) | 5 (12) | 5 (13) | 1 (2) | 9 (11) | 20 (10) |
| Current/former | 5 (12) | 12 (31) | 42 (86) | 46 (58) | 105 (50) |
| Mean Pack Years | 22.6 | 43.9 | 46.2 | 39.8 | 42 |
| Sex | |||||
| Male | 21 (51) | 10 (26) | 14 (29) | 38 (48) | 83 (40) |
| Female | 20 (49) | 29 (74) | 35 (71) | 42 (52) | 126 (60) |
| Median age, years (range) † | 51 (21–78) | 62 (45–78) | 59.5 (32–82) | 62 (41–82) | 59 (21–82) |
*
includes one pipe smoker,
†
age at diagnosis of metastatic disease