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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: J Neurosci Res. 2012 Mar 19;90(8):1489–1506. doi: 10.1002/jnr.23040

Figure 7. PARP-1 deletion decreases postnatal brain and body size.

Figure 7

Mice were weighed at P11 and then sacrificed for wet brain weight. (A) Both male and female PARP-1 KO mice weighed significantly less than their WT counterparts (*p<0.05). (B) The entire brain was removed and weighed immediately after sacrifice. PARP-1 KOs had significantly smaller brains than male and female WT mice (**p<0.01). To confirm that this change was a result of differences in forebrain size, rather than cerebellar or hind-brain changes, brains were sectioned and stained for cresyl violet. Hemisphere areas were measured on 4 sections per animal at the level of the SVZ. (C) PARP-1 KO mice had significantly smaller forebrain hemispheres than WT mice, with slightly larger difference between males (p<0.01) than females (p<0.05). All data are shown with SEM.