Table 1.
Characteristic | Category | No (%); or median (range) |
---|---|---|
Age (years) | ≥60; median | 121(33) 54 (21-82) |
Splenomegaly | Present | 52/366 (14) |
Hemoglobin (g/dl) | < 12; median | 149 (41) 12.3 (7.3 – 16.9) |
WBC (×109/1) | > 50; median | 38 (10) 9.1 (1.8 – 240.5) |
Platelets (×109/l) | > 450; median | 72 (20) 241 (81-1116) |
% marrow blasts | ≥ 5 | 33 (9) |
Peripheral blasts | Present | 67 (18) |
% marrow basophils | ≥ 5 | 44 (12) |
% peripheral basophils | ≥ 7 | 36 (10) |
Cytogenetic clonal evolution | Yes | 66 / 368 (18) |
Duration of chronic phase (mos) | < 12 | 36 (10) |
12-35 | 163 (44) | |
≥ 36 | 169 (46) | |
% Philadelphia-positive pretreatment | < 90 | 94 (26) |
Interferon alpha failure | Hematologic | 47 (13) |
Cytogenetic | 171 (46) | |
Intolerance | 148 (40) |