Table 2.

Prognostic Factors Associated with Survival

			Survival
Parameter	Category	n	%7-yr	%10-yr	Univariate p value	Hazard ratio	Multivariate p value
Age (years)	<60	247	82	75	<0.001	2.2	<0.001
	> = 60	121	66	55
CML duration (months)	<12	36	73	69	0.18		NS
	12-35	163	80	74
	>=36	169	74	62
Splenomegaly	No	314	80	73	<0.001		NS
	Yes	52	50	34
Hemoglobin (g/dL)	<10	26	52	41	0.001	2.53 N.S.	0.003 N.S.
	10-11.9	123	77	68
	>=12	219	79	72
Platelet (×109/L)	<=450	296	80	71	0.001		NS
	>450	72	64	55
WBC (×109/L)	<10	197	83	77	<0.001		NS
	10-50	133	73	60
	>50	38	53	49
%PB blasts	0	301	82	74	<0.001	2.45	<0.001
	>=1	67	50	42
%M blasts	<5	335	78	69	0.03		NS
	>=5	33	61	56
%PB baso	<7	332	78	69	0.11		NS
	>=7	36	61	56
%M baso	<5	324	80	73	<0.001	1.79	0.02
	>=5	44	48	33
CE	No	301	79	71	0.006	1.63	0.04
	Yes	66	64	56
% Ph+mets	<=90	111	89	79	0.002		NS
	>90	256	71	64
IFN failure	Hematologic	47	59	56	<0.001		NS
	Cytogenetic	171	83	77
	intolerance	148	74	62

PB =peripheral blood; M=marrow; baso = basophils; CE=clonal evolution; Ph+mets = Philadelphia + metaphases; IFN = interferon alpha;