Table 2.
Survival | |||||||
---|---|---|---|---|---|---|---|
Parameter | Category | n | %7-yr | %10-yr | Univariate p value | Hazard ratio | Multivariate p value |
Age (years) | <60 | 247 | 82 | 75 | <0.001 | 2.2 | <0.001 |
> = 60 | 121 | 66 | 55 | ||||
CML duration (months) | <12 | 36 | 73 | 69 | 0.18 | NS | |
12-35 | 163 | 80 | 74 | ||||
>=36 | 169 | 74 | 62 | ||||
Splenomegaly | No | 314 | 80 | 73 | <0.001 | NS | |
Yes | 52 | 50 | 34 | ||||
Hemoglobin (g/dL) | <10 | 26 | 52 | 41 | 0.001 | 2.53 N.S. | 0.003 N.S. |
10-11.9 | 123 | 77 | 68 | ||||
>=12 | 219 | 79 | 72 | ||||
Platelet (×109/L) | <=450 | 296 | 80 | 71 | 0.001 | NS | |
>450 | 72 | 64 | 55 | ||||
WBC (×109/L) | <10 | 197 | 83 | 77 | <0.001 | NS | |
10-50 | 133 | 73 | 60 | ||||
>50 | 38 | 53 | 49 | ||||
%PB blasts | 0 | 301 | 82 | 74 | <0.001 | 2.45 | <0.001 |
>=1 | 67 | 50 | 42 | ||||
%M blasts | <5 | 335 | 78 | 69 | 0.03 | NS | |
>=5 | 33 | 61 | 56 | ||||
%PB baso | <7 | 332 | 78 | 69 | 0.11 | NS | |
>=7 | 36 | 61 | 56 | ||||
%M baso | <5 | 324 | 80 | 73 | <0.001 | 1.79 | 0.02 |
>=5 | 44 | 48 | 33 | ||||
CE | No | 301 | 79 | 71 | 0.006 | 1.63 | 0.04 |
Yes | 66 | 64 | 56 | ||||
% Ph+mets | <=90 | 111 | 89 | 79 | 0.002 | NS | |
>90 | 256 | 71 | 64 | ||||
IFN failure | Hematologic | 47 | 59 | 56 | <0.001 | NS | |
Cytogenetic | 171 | 83 | 77 | ||||
intolerance | 148 | 74 | 62 |
PB =peripheral blood; M=marrow; baso = basophils; CE=clonal evolution; Ph+mets = Philadelphia + metaphases; IFN = interferon alpha;