Table 1.
Information of Selected SNPs of E2F1 and E2F2 Genes
| Gene | Selected SNPs | Location | TagSNPs | Function Predictedb | Position | Allele | MAFc |
|---|---|---|---|---|---|---|---|
| E2F1 | rs3213180 | 3′ UTR | NA | miRNA bing site | c.*914 | C>G | 0.056 |
| rs3213182 | 3′ near gene | Yes | NA | 3′ 256 | T>G | 0.067 | |
| rs3213183 | 3′ near gene | Yesa | NA | 3′ 527 | C>T | 0.267 | |
| E2F2 | rs6667575 | 5′ near gene | Yes | TFBS: G:GATA-2/A:GATA-1,2 | −1808 | G >A | 0.200 |
| rs3218121 | 5′ near gene | Yesa | TFBS | −604 | C >T | 0.100 | |
| rs2742976 | 5′ near gene | Yes | TFBS:G: STATx/T: STATx | −289 | G >T | 0.408 | |
| rs3218123 | 5′ near gene | NA | TFBS:G:SRY /T: Elk-1 | −143 | G >T | 0.140 | |
| rs3218148 | Intron 1 | Yesa | NA | 5926 | C >T | 0.492 | |
| rs3218203 | Intron 6 | Yes | NA | 20153 | G >C | 0.217 | |
| rs3218211 | 3′ UTR | NA | miRNA bing site | c.*578 | C >T | 0.500 |
a
complete LD with TagSNP: SNP rs3213183 in the 3′ near gene in complete LD (r2=1) with rs2071054; rs3218121 (in the 5′ near gene) is in complete LD (r2=1) with rs3218127 and that rs3218148 (in intron 1, MAF > 5%) is in complete LD (r2=1) with rs2038027 (in intron 3, MAF < 5%)
b
Function Predicted were used the bioinformatics tool of SNP: FuncPred, http://snpinfo.niehs.nih.gov/snpfunc.htm) and http://molsun1.cbrc.aist.go.jp/research/db/TFSEARCH.html
c
MAF of rs3213180, rs3218123, and rs3218211 were cited from http://www.ncbi.nlm.nih.gov/SNP, others were form Hapmap-CEU data