Table 3.
E2F1 and E2F2 Genotype and Allele Frequencies and their Association with Risk of SCCHN
| Genotypes | Cases, n (%) | Controls, n (%)b | Adjusted OR (95% CI)c | Ptrend-testc |
|---|---|---|---|---|
| E2F1 rs3213182 | ||||
| AAa | 880 (80.3) | 867 (79.6) | 1.00 (reference) | |
| AC | 208 (19.0) | 214 (19.6) | 0.96 (0.77–1.20) | |
| CC | 8 ( 0.7) | 9 ( 0.8) | 0.79 (0.29–2.18) | 0.624 |
| AC/CC | 216 (19.7) | 223 (20.5) | 0.95 (0.77–1.19) | |
| C allele | 224 (10.2) | 232(10.6) | ||
| E2F1 rs3213183 | ||||
| GGa | 552 (50.4) | 533 (48.9) | 1.00 (reference) | |
| AG | 445 (40.6) | 457 (41.9) | 0.95 (0.79–1.14) | |
| AA | 99 (9.0) | 100 (9.2) | 0.93 (0.68–1.27) | 0.522 |
| AG/AA | 544 (49.6) | 557 (51.1) | 0.95 (0.79–1.13) | |
| A allele | 643 (29.3) | 657 (30.1) | ||
| E2F1 rs3213180 | ||||
| GGa | 905 (82.6) | 873 (80.1) | 1.00 (reference) | |
| GC | 180 (16.4) | 211 (19.4) | 0.84 (0.67–1.06) | |
| CC | 11 ( 1.0) | 6 ( 0.5) | 1.63 (0.57–4.62) | 0.311 |
| GC/CC | 191 (17.4) | 217 (19.9) | 0.86 (0.69–1.08) | |
| C allele | 202 (0.09) | 223 (0.10) | ||
| E2F2 rs3218121 | ||||
| GGa | 933(85.1) | 926(84.9) | 1.00 ( reference ) | |
| GA | 158(14.4) | 160(14.7) | 0.95 (0.74–1.22) | 0.776 |
| AA | 5 (0.5) | 4 (0.4) | 1.18 (0.28–4.90) | |
| GA/AA | 163 (14.9) | 164 (15.1) | 0.96 (0.75–1.23) | |
| A allele | 168 (7.6) | 168 (7.7) | ||
| E2F2 rs2742976 | ||||
| GG | 413 (37.7) | 431 (39.5) | 1.00 (reference) | |
| GT | 538 (49.1) | 510 (46.8) | 1.06 (0.87–1.28) | |
| TT | 145 (13.2) | 149 (13.7) | 1.03 (0.78–1.36) | 0.721 |
| GT/TTa | 683 (62.3) | 659 (60.5) | 1.05 (0.88–1.26) | |
| T allele | 828 (37.8) | 808 (37.1) | ||
| E2F2 rs6667575 | ||||
| GG | 573 (52.3) | 579 (53.1) | 1.00 (reference) | |
| GA | 431 (39.3) | 424 (38.9) | 1.03 (0.85–1.24) | |
| AA | 92 (8.4) | 87 (8.0) | 1.13 (0.81–1.57) | 0.514 |
| GA/AAa | 523 (47.7) | 511 (46.9) | 1.04 (0.88–1.25) | |
| A allele | 615 (28.1) | 598 (27.4) | ||
| E2F2 rs3218203 | ||||
| CCa | 731 (66.7) | 719 (66.0) | 1.00 (reference) | |
| CG | 323 (29.5) | 333 (30.5) | 0.94 (0.77–1.14) | 0.855 |
| GG | 42 ( 3.8) | 38 ( 3.5) | 1.14 (0.71–1.81) | |
| CG/GG | 365 (33.3) | 371 (34.0) | 0.96 (0.80–1.15) | |
| G allele | 407 (18.6) | 409 (18.8) | ||
| E2F2 rs3218148 | ||||
| AAa | 347 (31.6) | 326 (29.9) | 1.00 (reference) | |
| AG | 517 (47.2) | 550 (50.5) | 0.87 (0.71–1.06) | 0.850 |
| GG | 232 (21.2) | 214 (19.6) | 1.01 (0.78–1.29) | |
| AG/GG | 749 (68.3) | 764 (70.1) | 0.91 (0.75–1.10) | |
| G allele | 981 (44.8) | 978 (44.9) | ||
| E2F2 rs3218211 | ||||
| CCa | 314 (28.7) | 286 (26.2) | 1.00 (reference) | |
| CT | 530 (48.3) | 551 (50.6) | 0.86(0.70–1.06) | 0.382 |
| TT | 252 (23.0) | 253 (23.2) | 0.90 (0.70–1.16) | |
| CT/TT | 782 (71.4) | 805 (73.8) | 0.87 (0.72–1.06) | |
| T allele | 1034 (47.2) | 1056 (48.5) | ||
| E2F2 rs3218123 | ||||
| GG | 828 (75.5) | 831 (76.2) | 1.00 (reference) | |
| GT | 243 (22.2) | 228 (20.9) | 1.00 (0.81–1.24) | |
| TT | 25 ( 2.3) | 31 (2.9) | 0.83 (0.47–1.42) | 0.724 |
| GT/TTa | 268 (24.5) | 259 (23.8) | 0.98 (0.80–1.21) | |
| T allele | 293 (13.4) | 290 (13.3) | ||
a
Assumed risk genotypes.
b
The observed genotype frequency among the control subjects were in agreement with Hardy-Weinberg equilibrium (p2 +2pq + q2 =1) (P = 0.541 for E2F1 rs3213180, P = 0.257 for E2F1 rs3213182, P = 0.494 for E2F1 rs3213183, P = 0.539 for E2F2 rs3218121, P = 0.144 for E2F2 rs2742976, P = 0.127 for E2F2 rs3218148, P = 0.400 for E2F2 rs3218203, P = 0.392 for E2F2 rs6667575, P = 0.328 for E2F2 rsrs3218211, P = 0.120 for E2F2 rs3218123)
c
Adjusted OR (95% CI) for age, sex, smoking status, alcohol use, and family history of cancer first-degree relatives in logistic regression models