Table 4.
Association and Stratification Analysis of the Combined Genotypes of E2F1 and E2F2 Polymorphisms and the Risk of Squamous Cell Carcinoma of the Head and Neck
| Variables | n, case/control | Number of combined risk genotypes of of E2F1 and E2F2 Polymorphismc
|
P trendd | ||||
|---|---|---|---|---|---|---|---|
| %(case/control)
|
Adjusted OR (95% CI)d
|
Adjusted OR (95% CI)d
|
|||||
| 0–4 | 5–8 | 9–10 | 0–4 vs. 5–8 | 0–4 vs. 9–10 | |||
| Totala | 1096/1090 | 31.0/33.5 | 59.5/60.1 | 9.5/6.4 | 1.04 (0.86–1.26) | 1.62 (1.14–2.30) | 0.045 |
| Tumor site | |||||||
| Oropharynx | 557/1090 | 28.6/33.5 | 61.2/60.1 | 10.2/6.4 | 1.14 (0.90–1.44) | 1.76 (1.17–2.64) | 0.016 |
| Non-oropharynxb | 539/1090 | 33.6/33.5 | 57.7/60.1 | 8.7/6.4 | 0.92 (0.72–1.18) | 1.43 (0.90–2.26) | 0.556 |
| Age | |||||||
| ≤ median (57 years) | 585/572 | 30.1/32.7 | 60.7/61.4 | 9.2/5.9 | 1.07 (0.82–1.39) | 1.74 (1.07–2.85) | 0.083 |
| > median (57 years) | 511/518 | 32.1/34.4 | 58.1/58.7 | 9.8/7.0 | 1.03 (0.78–1.35) | 1.47 (0.89–2.42) | 0.261 |
| Sex | |||||||
| Male | 826/832 | 31.2/32.6 | 59.1/60.7 | 9.7/6.7 | 1.00 (0.80–1.24) | 1.48 (1.00–2.20) | 0.191 |
| Female | 270/258 | 30.4/36.4 | 60.7/58.1 | 8.9/5.4 | 1.21 (0.82–1.79) | 2.09 (0.98–4.48) | 0.074 |
| Smoking status | |||||||
| Never | 304/535 | 30.9/33.3 | 58.2/60.4 | 10.9/6.4 | 1.03 (0.76–1.41) | 1.85 (1.07–3.17) | 0.109 |
| Ever | 792/555 | 31.1/33.7 | 60.0/59.8 | 9.0/6.5 | 1.04 (0.82–1.33) | 1.41 (0.90–2.21) | 0.238 |
| Drinking status | |||||||
| Never | 297/473 | 31.7/36.2 | 58.3/58.4 | 10.1/5.5 | 1.16 (0.84–1.59) | 2.19 (1.22–3.95) | 0.027 |
| Ever | 799/617 | 30.8/31.4 | 60.0/61.4 | 9.3/7.1 | 0.99 (0.78–1.25) | 1.32 (0.86–2.04) | 0.414 |
| Family history of cancer in first-degree relatives | |||||||
| Yes | 662/678 | 30.2/32.2 | 59.8/61.7 | 10.0/6.2 | 1.02 (0.80–1.30) | 1.64 (1.05–2.57) | 0.125 |
| No | 434/412 | 32.3/35.7 | 59.0/57.5 | 8.8/6.8 | 1.11 (0.82–1.50) | 1.53 (0.87–2.66) | 0.173 |
The distribution of three groups of the combined genotypes between the cases and controls for total samples was statistically significant (P = 0.023).
included oral cavity, larynx and hypopharynx.
The number represents the numbers of risk genotypes: the risk genotypes used for the calculation were rs3213182 AA, rs3213183 GG, rs3213180 GG, rs3218121 GG, rs2742976 GT+TT, rs6667575 GA+AA, rs3218203 CC, rs3218148 AA, rs3218211 CC, rs3218123 GT+TT genotypes.
Adjusted OR (95% CI) for age, sex, smoking status, alcohol use, family history of cancer first-degree relatives in logistic regression models.