Table 2.
Summary of published reports of dental manifestations of Gaucher disease
| Author | Age /Sex | Findings | Treatment | SPX | Site | ||||
|---|---|---|---|---|---|---|---|---|---|
| Bender, 1938 | 13/F | Cyst-like radiolucency & loss of trabecular structure in premolar & molar regions; generalized porosity in man region | Extraction of lower 1st molars | yes | man & max | ||||
| Bender, 1959 follow up | Distinct radiolucent areas; further loss of trabecular structure; endosteal bone degeneration & thickness reduction; episodes of spontaneous hemorrhage in region of hard palate | see above | |||||||
| Bender et al, 1996 follow up | Marked improvement in radiolucency with re-formation of trabeculae | Uncomplicated extraction of posterior teeth; ERT (1991) subsequently | |||||||
| Moch et al, 1953 | 39/F | Pseudo-cystic radiolucent areas on both sides of man; alveolar abscess of upper right 2nd premolar | Extraction of abscessed tooth & curettage of peri-apical area (6000 units penicillin qd + 500cc whole blood) | no | man | ||||
| Spiegel 1957 | 19/F | Radiolucency & loss of trabecular structure in premolar & molar region; osteolysis in left premolar region of max; prolonged bleeding after minor surgery | Removal of tissue flap over lower right 3rd molar | no | man & max | ||||
| Michan-owicz et al, 1967 | 21/M | Small & large carious lesions in many of man & max teeth; radiolucency in right 3rd molar and 1st first molar; generalized vacuolation & osteoporosis in man | Extraction of man right 3rd molar, left 1st molar, & max left 2nd molar | yes | man | ||||
| Weigler et al, 1967 | 28/M | Large radiolucent region from 1st premolar to 3rd molar; widening of marrow spaces; loss of lamina dura at root of lower left 2nd premolar & 1st molar | Extraction & currettage of lower left 1st molar | no | man | ||||
| Bildman 1972 | 16/F | Radiolucent areas in body of man | Extraction of upper and lower right molars | no | man | ||||
| Hall et al, 1985 | 47/M | (Gaucher) bony lesion in left man with infarction & secondary infection | Debridement of left man body & ramus; extraction of man 2nd premolar & 1st + 2nd molar; IV & oral penicillin | yes | man | ||||
| Heas-man, 1991 | 40/F | Hemorrhagic lesions in face & lips; areas of radiopacity in premolar & molar regions of man; generalized, edematous gingivitis | yes | man | |||||
| Kara-bulut et al, 1997 | 14/F | Diffuse osteopenia; trabecular loss; coarsening of man & max; opacification of sphenoid & max sinuses due to expansion of medullary spaces | yes | man & max & sphen-oid bones | |||||
| Horwitz et al, 2007 | 47/F | Bilateral cyst-like lesions; severe root resorption in premolar-molar region; enlargement of bone marrow space; loss of trabecular structure; effacement of cortical borders of man canal | Scaling; root planing; access flap surgery; extraction of 3 teeth (2,15,16) | no? | man | ||||
SPX = splenectomy ; man = mandible; max = maxilla; ERT = enzyme replacement therapy; IV = intravenous