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. 2012 Apr 20;287(24):19997–20006. doi: 10.1074/jbc.M111.325670

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Stoichiometry of R1-Venus, KDR1-Venus, and KLB-Venus after FGF21 addition. A, KLB-Venus was expressed with either R1-Cerulean or KDR1-Cerulean for N&B analysis after FGF21 treatment. KLB-Venus showed a significant increase in aggregation state after the addition of FGF21 that was abolished by lactose treatment. KLB-Venus oligomerization did not significantly change after FGF21 addition when co-expressed with R1-Cerulean or KDR1-Cerulean. B, R1-Cerulean and KDR1-Cerulean were either singly expressed or co-expressed with KLB-Cerulean. R1-Venus showed a nearly 2-fold increase in oligomerization state after the addition of FGF21 when co-expressed with KLB-Cerulean. KDR1-Venus did not show the same effects after the addition of FGF21 when co-expressed with KLB-Cerulean, suggesting that dimerization of R1-Venus after the addition of FGF21 depends on the C terminus of the receptor. * indicates a p value of <0.05 by Student's t test.