TABLE 1.
Parameters of EAAT3 model
Rate constants of the transport process and channel opening/closing at −70 mV are shown. Electrogenic reactions are defined by zδ values, which correspond to the product of the charge and the fraction of the electric field the charge is moved across the membrane. Clockwise transitions in the model scheme are denoted as “forward reactions.”
| Reaction | Forward | Backward | zδ | Changed parameters for D83A |
|
|---|---|---|---|---|---|
| Forward | Backward | ||||
| 1 | 1.00·104m−1 s−1 | 2.50·103 s−1 | 0.20 | ||
| 2 | 1.00·104m−1 s−1 | 2.50·103 s−1 | 0.20 | ||
| 3 | 6.80·106m−1 s−1 | 3.00·102 s−1 | −0.40 | ||
| 4 | 6.00·1011m−1 s−1 | 7.00·102 s−1 | |||
| 5 | 6.00·1011m−1 s−1 | 7.00·102 s−1 | 0.40 | ||
| 6 | 6.80·106m−1 s−1 | 3.00·102 s−1 | |||
| 7 | 1.00·104m−1 s−1 | 1.00·103 s−1 | 0.55 | ||
| 8 | 5.50·102 s−1 | 5.00·102 s−1 | 1.00·105 s−1 | 6.59 s−1 | |
| 9 | 8.00·102 s−1 | 4.00·104m−1 s−1 | 0.45 | ||
| 10 | 6.00·103 s−1 | 9.00·1010m−1 s−1 | |||
| 11 | 3.00·103 s−1 | 4.00·105m−1 s−1 | |||
| 12 | 5.00·102 s−1 | 2.00·105m−1 s−1 | |||
| 13 | 4.00·103 s−1 | 1.00·106m−1 s−1 | 0.20 | ||
| 14 | 1.00·106m−1 s−1 | 1.00·103 s−1 | |||
| 15 | 50 s−1 | 5.00 s−1 | 0.40 | 131.45 s−1 | 1.00·105 s−1 |
| 16 | 8.00·102 s−1 | 1.00·104m−1 s−1 | |||
| 17 | 0.80 s−1 | 1.00·10−2 s−1 | 0.11 s−1 | 19.19 s−1 | |