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. 2012 Apr 17;287(24):20027–20036. doi: 10.1074/jbc.M111.334953

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 2. — An engineered TnC corrects DCM TnT ΔK210 thin filament Ca²⁺ sensitivity. A, the Ca²⁺-dependent changes in IAANS fluorescence for control Tn_IAANS^T53C (open squares), TnC M45Q Tn_IAANS^T53C (semicircles), TnT ΔK210-TnC M45Q Tn_IAANS^T53C (filled squares), and TnT ΔK210 Tn_IAANS^T53C (inverted triangles) reconstituted thin filaments as a function of pCa. B, the Ca²⁺-dependent changes in IAANS fluorescence for control Tn_IAANS^T53C (open squares), TnC M45Q/S69D Tn_IAANS^T53C (filled diamonds), TnT ΔK210-TnC M45Q/S69D Tn_IAANS^T53C (filled inverted triangles), and TnT ΔK210 Tn_IAANS^T53C (open inverted triangles) reconstituted thin filaments as a function of pCa.