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An engineered TnC corrects ischemic TnI-(1–192) thin filament Ca2+ sensitivity. The figure shows the Ca2+-dependent increase in IAANS fluorescence for control TnIAANST53C (□), TnI-(1–192) TnIAANST53C (▵), TnI-(1–192)-TnC S69D/D73N TnIAANST53C (▴), and TnC S69D/D73N TnIAANST53C (♢) reconstituted thin filaments as a function of pCa.
