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. 2012 Apr 17;287(24):20027–20036. doi: 10.1074/jbc.M111.334953

FIGURE 7.

FIGURE 7.

Engineered TnC constructs functionally correct DCM TnT ΔK210 and ischemic TnI-(1–192) skinned cardiac muscle force generation. A, the Ca2+-dependent force generation for skinned trabeculae exchanged with control TnIAANST53C (□), TnT ΔK210 TnIAANST53C (▿), and TnT ΔK210-TnC M45Q/S69D TnIAANST53C (▾). B, the Ca2+-dependent force generation for skinned trabeculae exchanged with control TnIAANST53C (□), TnI-(1–192) TnIAANST53C (▵), and TnI-(1–192)-TnC S69D/D73N TnIAANST53C (▴). Data traces were individually normalized.